Synthetic protein. The second component of our circuit is a remodeled PHA synthase protein, designed to be more efficient and incorporate more desirable monomer subunits. Our platform is designed to produce the promising copolymer poly(3-hydroxybutyrate-co-4-hydroxybutyrate). However, low levels of 4-hydroxybutyrate (4HB) make the polymer brittle and crystalline. Our engineered protein upregulates levels of the desirable 4HB monomer, leading to a 4000% increase in 4HB yield and producing a stronger, more durable polymer.
Click and drag the protein in the frame at right to rotate the 3-D model. Uncheck the “auto rotate” box to stop the automatic rotation of the figure.