Research bibliography

  • G.C. Barnard, J.D. McCool, D.W. Wood, and T.U. Gerngross. Integrated recombinant protein expression and purification platform based on Ralstonia eutropha. Applied and Environmental Microbiology, 71(10):5735–5742, 2005.
  • G.Q. Chen and Q. Wu. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials, 26(33):6565–6578, 2005.
  • J. Garcia-Ojalvo, M.B. Elowitz, and S.H. Strogatz. Modeling a synthetic multicellular clock: Repressilators coupled by quorum sensing. Proceedings of the National Academy of Sciences, 101(30):10955–10960, July 2004.
  • Y. Jia, W. Yuan, J. Wodzinska, C. Park, A.J. Sinskey, and J.A. Stubbe. Mechanistic studies on class I polyhydroxybutyrate(phb) synthase from Ralstonia eutropha: Class I and III synthases share a similar catalytic mechanism. Biochemistry (Washington), 40(4):1011–1019, 2001.
  • S.N. Jogdand. BIOPOL - PHB Accumulation in Micro-organisms - General structure & Properties of PHA. Available from World Wide Web: http://members.rediff.com/jogsn/bp6.htm [cited 24 January 2008].
  • S.J. Lee, J.P. Park, T.J. Park, S.Y. Lee, S. Lee, and J.K. Park. Selective immobilization of fusion proteins on poly(hydroxyalkanoate) microbeads. Analytical Chemistry, 77(17):5755–5759, 2005.
  • S.J. Liu and A. Steinbüchel. A novel genetically engineered pathway for synthesis of poly(hydroxyalkanoic acids) in Escherichia coli. Applied and Environmental Microbiology, 66(2):739–743, February 2000.
  • L.L. Madison and G.W. Huisman. Metabolic engineering of poly(3-hydroxyalkanoates): From DNA to plastic. Microbiology and Molecular Biology Reviews, 63(1):21–53, 1999.
  • D.P. Martin and S.F. Williams. Medical applications of poly-4-hydroxybutyrate: a strong flexible absorbable biomaterial. Biochemical Engineering Journal, 16(2):97–105, 2003.
  • E.F. Pettersen, T.D. Goddard, C.C. Huang, G.S. Couch, D.M. Greenblatt, E.C. Meng, and T.E. Ferrin. UCSF Chimera — a visualization system for exploratory research and analysis. Journal of Computational Chemistry, 25(13):1605–1612, October 2004.
  • S. Philip, T. Keshavarz, and I. Roy. Polyhydroxyalkanoates: biodegradable polymers with a range of applications. Journal of Chemical Technology & Biotechnology, 82(3):233–247, March 2007.
  • Y. Poirier, D.E. Dennis, K. Klomparens, and C. Somerville. Polyhydroxybutyrate, a biodegradable thermoplastic, produced in transgenic plants. Science, 256(5056):520–523, April 1992.
  • M. Pötter and A. Steinbüchel. Poly(3-hydroxybutyrate) granule-associated proteins: Impacts on poly(3-hydroxybutyrate) synthesis and degradation. Biomacromolecules, 6(2):552–560, 2005.
  • S. Resch, K. Gruber, G. Wanner, S. Slater, D. Dennis, and W. Lubitz. Aqueous release and purification of poly(β-hydroxybutyrate) from Escherichia coli. Journal of Biotechnology, 65(2-3):173–182, October 1998.
  • Y. Saito, S. Nakamura, M. Hiramitsu, and Y. Doi. Microbial synthesis and properties of poly(3-​hydroxybutyrate-​co-​4-​hydroxybutyrate): PHB and hydroxyalkanoate polymers. Polymer International, 39(3):169–174, 1996.
  • J.A. Stubbe and J. Tian. Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase. Natural Product Reports, 20:445–457, 2003.
  • K. Sudesh, H. Abe, and Y. Doi. Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Progress in Polymer Science, 25(10):1503–1555, 2000.
  • H.E. Valentin and D. Dennis. Production of poly(3-​hydroxybutyrate-​co-​4-​hydroxybutyrate) in recombinant Escherichia coli grown on glucose. Journal of Biotechnology, 58(1):33–38, October 1997.
  • R.A.J. Verlinden, D.J. Hill, M.A. Kenward, C.D. Williams, and I. Radecka. Bacterial synthesis of biodegradable polyhydroxyalkanoates. Journal of Applied Microbiology, 102(6):1437–1449, 2007.
  • W. Yuan, Y. Jia, J. Tian, K.D. Snell, U. Müh, A.J. Sinskey, R.H. Lambalot, C.T. Walsh, and J.A. Stubbe. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: Characterization and substrate specificity studies. Archives of Biochemistry and Biophysics, 394(1):87–98, October 2001.
  • M. Zinn, B. Witholt, and T. Egli. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Advanced Drug Delivery Reviews, 53:5–21, 2001.

Media sources

History

PHA granules (1926 background)
J.A. Stubbe and J. Tian. Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase. Natural Product Reports, 20:445–457, 2003.
Various monomers (1974 background)
W. Yuan, Y. Jia, J. Tian, K.D. Snell, U. Müh, A.J. Sinskey, R.H. Lambalot, C.T. Walsh, and J.A. Stubbe. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: Characterization and substrate specificity studies. Archives of Biochemistry and Biophysics, 394(1):87–98, October 2001.
Biosynthesis plasmid (1988 background)
J. Kidwell, H.E. Valentin, and D. Dennis. Regulated expression of the Alcaligenes eutrophus PHA biosynthesis genes in Escherichia coli. Applied Environmental Microbiology, 61(4):1391–1398, April 1995.
PHA synthase protein (2020 background)
J.A. Stubbe and J. Tian. Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase. Natural Product Reports, 20:445–457, 2003.

Our Vision

Decomposing bioplastic bottles
L.L. Madison and G.W. Huisman, “Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic”. Microbiology and Molecular Biology Reviews, 63(1):21–53, 1999.

Design

PHA polymer at various magnification levels (edited)
S.J. Liu and A. Steinbüchel, “Exploitation of butyrate kinase and phosphotransbutyrylase from Clostridium acetobutylicum for the in vitro biosynthesis of poly(hydroxyalkanoic acid)”. Applied Microbiology and Biotechnology, 53(5):545‒552, May 2000.

Impact

Bliss
by dezinerfolio (Flickr user navdeepraj), 19 May 2007
Rochester Factory
by seraph_ben (Flickr user seraph), 4 December 2006
Vondelpark Stork in Trash
by -Andrew- (Flickr user americanidle), 5 July 2006
50 years BUBBLE WRAP
by Harald Schmid (Flickr user lf3180), 11 October 2007
all rights reserved
Sunny Side Up
by code poet (Flickr user alphageek), 3 September 2006