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TBMS works by spraying it on the tongue, it contains ligands (developed by our genetic engineering studies) that will stimulate or inhibite TRCs affecting taste sensations. For example, it has been discovered that the gene TAS2r38 shows variations that cause some children and people to be especially sensitive to bitter tastes. Our spray will inhibit such receptor and will result in a sweet taste signal (through blocking of the vegetable (bitter) taste). Several versions of the active ingredient will be available. For young kids it will become more important to block the bitterness to help them like their vegetables and promote intake of important nutrients. In older children and adults, the goal could be to block and modify the sweet receptor; a candy could have sour and bitter taste. The ligands will bind to the targeted receptors and conformational changes in the taste cell membrane will occur in such a way that when the food molecules come into contact with particular receptors they will be activated.
We have envisioned two main versions (within each one several versions will exist since depending on the needs, different molecular markers will be added). Version 1 will contain only the taste bud modifying ligands. Version 2 will also have nanoparticles (for the already obese individuals). These nanoparticles will react with some enzymes in the stomach and will provide a feeling of fullness such as the sensation felt by patients that have had gastric bypass.