C.H.A.N.G.E. - Counteracting HIV/AIDS through New Gene Enhancement

Reference Sources

Bell, C.; Devarajan, S.; Gersbach, H.;. “The Long-run Economic Costs of AIDS: Theory and an Application to South Africa.” The World Bank. Jun 2003. 10 Jan. 2009. .

Chiu, Y.; Soros, V.; . Kreisberg, J.; Stopak, K.; Yonemoto, W.; Greene, W. “Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.” Nature. 4 May 2005. 4 Jan. 2009..

Conrad, Steve. “Implications.” Biology at the University of Arizona. 2007. 2 Jan. 2009 .

Cichocki, Mark. “The History of HIV/AIDS.” About. 23 Jul. 2007. 19 Dec. 2008 .

Durai, S.; Mani, M.; Kandavelou, K.; Wu, J.; Porteus, M.; Srinivasan, C. . “Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells .” Oxford Journals. 26 Oct. 2006. 7 Jan. 2009 .

Engel, Jonathan. The Epidemic : A Global History of AIDS. New York: Smithsonian Books/Collins, 2006.

Gommans, W.; Haisma, H.; Rots.; M. “Engineering Zinc Finger Protein Transcription Factors: The Therapeutic Relevance of Switching Endogenous Gene Expression On or Off at Command.” Science Direct. Jun. 2005. 6 Jan. 2009 .

Gonçalves, Manuel AFV. “Adeno-associated virus: from defective virus to effective vector.” The Virology Journal. 6 May 2005. 4 Jan. 2009 .

Habasque, C,; Aubry, F.; Jégou, B.; Samson, M. “Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.” The Oxford Journals. May 2002. 5 Jan. 2009.

Human Genome Project . “Gene Therapy.” Human Genome Project. 19 Sept. 2008. 7 Jan. 2009 .

Hunt, Richard. “HUMAN IMMUNODEFICIENCY VIRUS AND AIDS Types, Sub-types and Co-receptors.” Biomedical Sciences, USC. 24 Oct. 2008. 12 Jan. 2009 .

Judson, Karen. Genetic Engineering: Debating the Benefits and Concerns. Berkeley Heights: Enslow Publishers, 2001.

Kay, M.; Liu, D.; Hoogerbrugge, P. “Gene therapy.” Proceedings of the National Academy of Sciences of the United States. 25 Nov. 1997. 2 Jan. 2009 .

Kimball, J. “Gene Therapy II. “ Kimball’s Online Biology Textbook. 6 Aug. 2007. 2 Jan. 2009 .

Luban, J.; Sebastian, S. “TRIM5α selectively binds a restriction-sensitive retroviral capsid.” Retrovirology. 20 Jun. 2005. 6 Jan. 2009 .

Marmor, M; Hertzmark, K; Thomas, S. M.; Halkitis, P. N.; Vogler, M. “Resistance to HIV Infection.” Pub Med Central. 2006. 11 Jan. 2009 .

Panno, Joseph. Gene Therapy: Treating Disease by Repairing Genes. New York: Facts On File, 2005. Panno, Joseph. Stem Cell Research. New York: Facts On File, 2005.

Schoofs, Mark. “A Doctor, a Mutation and a Potential Cure for AIDS .” The Wall Street Journal. 7 Nov. 2008. 27 Dec. 2008 .

Twyman, Richard. Advanced Molecular Biology. Oxford: Bios Scientific Publishers, 1998

US Department of Health. “The HIV Life Cycle.” AIDSinfo. May 2005. 2 Jan. 2009 .

Verma, Inder. “GENE THERAPY: POTENTIAL, PITFALLS AND PROSPECTS.” National Institute of Health. Dec. 1998. 3 Jan. 2009 .

Whittemore, Kurt. “Effects of Zinc Finger Domain Quantity in Zinc Finger Nucleases on Homologous Recombination Frequency.” Apr. 2008. 5 Jan. 2009 .

Xie, Q.; Bu, W.; Bhatia, S.; Hare, J.; Somasundaram, T.; Azzi, A.; Chapman, M. “The atomic structure of Adeno-associated virus (AAV-2), a vector for human gene therapy.” Proceedings of the National Academy of Sciences of the United States. 5 Jun. 2002. 6 Jan. 2009.

Yount, Lisa. The Discovery of the AIDS Virus. Farmington Hills: Greenhaven Press, 2003.

Media Images

Digital image. Cosmos. 14 Jan. 2009. 9 Apr. 2009 http://www.cosmosmagazine.com/files/imagecache/feature/files/20080520_aids_ribbon.jpg.

History

Digital image. Gdemo. 17 Dec. 2008. 9 Apr. 2009 http://big5.gdemo.gov.cn/gate/big5/www.gdemo.gov.cn/english/News/china/200 805/W020080509347382337324.jpg.

Digital image. Daylife. 9 Apr. 2009. 9 Apr. 2009 http://cache.daylife.com/imageserve/00mw2TS5mRblm/610x.jpg.

Digital image. In Their Own Words. 25 May 2001. 9 Apr. 2009 http://aidshistory.nih.gov/transcripts/bios/biopics/Gallo.jpg.

Digital image. Daylife. 9 Apr. 2009. 9 Apr. 2009 http://cache.daylife.com/imageserve/00mw2TS5mRblm/610x.jpg.

Digital image. Chemistry, Structures, and 3D Models. 4 Mar. 2009. 9 Apr. 2009 http://www.3dchem.com/imagesofmolecules/Didanosine.jpg.

Digital image. GA International. 30 Aug. 2005. 9 Apr. 2009 http://www.ga-international.com/PCR%20LABEL.100_0879CROP.jpg>

Digital image. HRSA. 29 July 2008. 9 Apr. 2009 http://hab.hrsa.gov/livinghistory/images/timeline/1996-2000/cocktail.jpg.

Digital image. Project Inform. 4 Apr. 2008. 9 Apr. 2009 http://www.projectinform.org/info/ccr5/ccr5_02.gif.

Digital image. Wordpress. 4 Feb. 2009. 9 Apr. 2009 http://sciencedesk.files.wordpress.com/2009/02/syringe.jpg.

Present Technology

Digital image. Migraine Headache Control. 13 June 2007. 9 Apr. 2009 http://migraineheadachecontrol.com/images/Pills.jpg.

Digital image. Nature. 7 Dec. 2007. 9 Apr. 2009 http://www.nature.com/nrd/journal/v6/n12/fig_tab/nrd2424_F2.html.

Digital image. Wikimedia. 28 June 2008. 9 Apr. 2009 http://upload.wikimedia.org/wikipedia/en/9/9a/HIV_protease_1KJF.png.

Digital image. Wikipedia. 28 June 2008. 9 Apr. 2009 http://en.wikipedia.org/wiki/File:HIV_protease_1EBY.png.

Digital image. Medscape. 17 July 2003. 9 Apr. 2009 http://www.medscape.com/content/2003/00/45/86/458640/art- nm458640.fig4.gif.

Breakthroughs

Digital image. Webs. 4 Apr. 2009. 9 Apr. 2009 http://movaje.webs.com/gene%20therapy.jpg.

Digital image. Plyojump. 10 Nov. 2005. 9 Apr. 2009 http://www.plyojump.com/courses/biology/images/gene_therapy.jpg.

Digital image. Vechnayamolodost. 2 July 2008. 9 Apr. 2009 http://www.vechnayamolodost.ru/img/03-08/zinc-finger.jpg.

Design

Digital image. BBIOO. 9 June 2007. 9 Apr. 2009 http://www.bbioo.com/bio101/UploadFiles/200706/20070610100735188.gif.

Digital image. FDA. 16 Aug. 2000. 9 Apr. 2009 http://www.fda.gov/fdac/features/2000/gene.html.

Future

Digital image. Wikimedia. 29 July 2008. 9 Apr. 2009 http://upload.wikimedia.org/wikipedia/commons/d/d7/HIV_Epidem.png.

Impact

Digital image. Webs. 6 Apr. 2009. 9 Apr. 2009 http://biotechcenter.webs.com/ExpensivePill.jpg.

Digital image. Good Housekeeping. 11 Aug. 2008. 9 Apr. 2009 http://www.goodhousekeeping.com/cm/goodhousekeeping/images/xX/expensive-pills-de.jpg.

Digital image. Life Changing Apparel. 3 Feb. 2009. 9 Apr. 2009 https://www.lifechangingapparel.com/images/happy_faces_africa_j1rx.jpg.

Digital image. Cynical-C Blog. 22 May 2008. 9 Apr. 2009 http://www.cynical- c.com/archives/bloggraphics/monkeythurs.jpg.

Digital image. Top News. 1 Dec. 2008. 9 Apr. 2009 http://www.topnews.in/files/world-aids.jpg.