Multiple Sclerosis
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Multiple Sclerosis is a progressive autoimmune disease where autoimmune T cells damage the myelin sheath of nerve cells, as depicted in the .gif to the right. The damage done to the myelin sheath causes a disruption in electrical impulses, which are critical for sending neural messages. By disrupting neural messages, MS causes muscle spasms, stiffness, or paralysis, as well as many other symptoms. Part of the way in which OBHT helps to better treat MS is that by activating the effects of histamine on autoreactive T cells it rearranges the patterns of integrin on the surface of the T cells which prevents them from being able to adhere and cause damage to the myelin sheath.
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Autoreactive T cells attack the myelin sheath with assistance from autoreactive B cells which activate T cells through antigen presentation (as depicted in the .gif to the left), cytokine production, antibody production (as depicted in the .gif above), and the formation of lymphoid structures. Part of the way in which OBHT helps to better treat MS is that by activating the effects of histamine on autoreactive T cells it interferes with phosphorylation that occurs on the communication pathways between B cells and T cells, preventing T cell activation.
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