The Spiegel-Wycis apparatus was first introduced.

Dr. Dandy theorized that TN was caused by a blood vessel pressing against the nerve. Dr. Janetta, who first performed microvascular decompression, expanded on the topic.

Meanwhile, Phenytoin medicine became popular among TN patients. It claimed to prevent TN pain attacks.

Balloon compression was developed by S. Mullan.

Carbamazepine was introduced as a drug to treat TN.

The first stereotactic apparatus was built by Martin Kirschner.

A Greek, Aretaeus of Cappeldolcia, recommended bloodletting and poison bandages as treatment.

John Locke, an English philosopher, recorded more accurate observations of a countess suffering from TN.

An Arabian scholar proposed that resting in a dark room after drinking wine would relieve pain.

The first thermoresponsive hydrogel injection procedure will be performed successfully on a TN patient. 

Drs. Love and Svien discovered the positives of anesthetics and began to perform nerve-compressing procedures.

Dr. Harris first successfully injected alcohol into the gasserian ganglion.