In order for PACI to become a reality, breakthroughs are necessary.
Measurement of Plaques and Tangles
PACI relies upon the Alzheimer’s Cranial Index (ACI). In order to establish this virtual library of brain scans, it is necessary to have an accurate measure of the amount of plaques and tangles in the brain for each stage of the disease. This will allow doctors to compare a patient's scan to one from the index, in order to accurately diagnose one’s stage of the disease and track its progression over time.
Cause of Alzheimer’s
Currently it is not known if plaques and tangles cause the disease, or are formed as a result of having the disease.